劉紅星 /北京陸道培血液病研究院執(zhí)行院長(zhǎng)、陸道培醫(yī)院病理和檢驗(yàn)醫(yī)學(xué)科主任

專業(yè)經(jīng)驗(yàn)：

從事臨床醫(yī)師工作3年，血液病實(shí)驗(yàn)診斷及相關(guān)研究工作22年。在白血病發(fā)病機(jī)制、新白血病分子分型鑒定、基因突變分型等方面有多項(xiàng)國(guó)際原創(chuàng)性發(fā)現(xiàn)。以通訊/第一作者于Nature Medicine、Blood等中英文期刊發(fā)表學(xué)術(shù)論文150余篇。所指導(dǎo)的工作和培養(yǎng)的團(tuán)隊(duì)成員于ASH、ASHG、JSH等國(guó)際學(xué)術(shù)會(huì)議做Oral、Poster會(huì)議報(bào)告120余人次。

 執(zhí)業(yè)經(jīng)歷：

2022-    北京陸道培血液病研究院  執(zhí)行院長(zhǎng)

2018-2021   北京陸道培血液病研究院  副院長(zhǎng)

2017-   北京陸道培醫(yī)院、河北燕達(dá)陸道培醫(yī)院        病理和檢驗(yàn)醫(yī)學(xué)科  主任

2015-2016   河北燕達(dá)陸道培醫(yī)院  病理和檢驗(yàn)醫(yī)學(xué)科  主任

2012-2015   陸道培血液?腫瘤中心   醫(yī)學(xué)檢驗(yàn)科   主任

2011-2012   北京市道培醫(yī)院   檢驗(yàn)中心   副主任

2006-2011   北京市道培醫(yī)院   分子診斷室  分子診斷臨床應(yīng)用和研究

2003-2006   北京大學(xué)工學(xué)院   生物醫(yī)學(xué)工程專業(yè)   碩士

2000-2003   山東省日照市東港區(qū)婦幼保健院  臨床醫(yī)師

1995-2000    濱州醫(yī)學(xué)院   臨床醫(yī)學(xué)專業(yè)   學(xué)士

社會(huì)職稱：

第七屆北京優(yōu)秀醫(yī)師；中國(guó)非公立醫(yī)療機(jī)構(gòu)協(xié)會(huì)病理學(xué)專委會(huì)常務(wù)委員兼血液病學(xué)組組長(zhǎng)、中國(guó)醫(yī)藥衛(wèi)生文化協(xié)會(huì)實(shí)驗(yàn)診斷與社會(huì)化服務(wù)專委會(huì)常務(wù)委員、中國(guó)非公立醫(yī)療機(jī)構(gòu)協(xié)會(huì)檢驗(yàn)醫(yī)學(xué)專委會(huì)常務(wù)委員、中國(guó)抗癌協(xié)會(huì)腫瘤基因診斷專委會(huì)/臨床檢驗(yàn)與伴隨診斷專委會(huì)/腫瘤疫苗專委會(huì)委員、北京非公立醫(yī)療機(jī)構(gòu)協(xié)會(huì)檢驗(yàn)專委會(huì)副主任委員、北京免疫學(xué)會(huì)理事等；國(guó)家病理質(zhì)控中心非公組專家；河北省臨床檢驗(yàn)中?室間質(zhì)量評(píng)價(jià)專家委員會(huì)員；《中華醫(yī)學(xué)雜志》通訊編委；《白血病?淋巴瘤》、《分子診斷與治療雜志》、Proceedings of Anticancer Research 、International Journal of Medical Reviews 編委。

發(fā)明專利：

劉紅星，朱平，王倩，蔡鵬，童春容. 一種用于檢測(cè)細(xì)胞嵌合狀態(tài)或個(gè)體識(shí)別的基因檢測(cè)試劑盒. 專利號(hào)：CN101671736B

劉紅星，滕文，王芳，張陽，陳雪. 白血病融合基因篩查檢測(cè)方法. 專利申請(qǐng)?zhí)枺篊NL201710580828.2

劉紅星，滕文，王芳，張陽，陳雪. 白血病融合基因篩查檢測(cè)試劑盒. 專利申請(qǐng)?zhí)枺篊NL201710581443.8

劉紅星，王彤，滕文. 用于PCR擴(kuò)增的標(biāo)本及其制備方法、保存方法和使用方法. 專利申請(qǐng)?zhí)枺篊NL201710845441.5

專業(yè)/培訓(xùn)證書

國(guó)家醫(yī)師執(zhí)業(yè)資格證書

二級(jí)實(shí)驗(yàn)室生物安全培訓(xùn)證書

遺傳咨詢師證書

藥物臨床試驗(yàn)質(zhì)量管理規(guī)范（GCP）培訓(xùn)證書

所獲獎(jiǎng)勵(lì)

2014.10   第76屆日本血液學(xué)年會(huì)Travel Award   日本血液學(xué)會(huì)

2013.10   第75屆日本血液學(xué)年會(huì)Travel Award   日本血液學(xué)會(huì)

2012.10   第74屆日本血液學(xué)年會(huì)Travel Award   日本血液學(xué)會(huì)

2011.10   第73屆日本血液學(xué)年會(huì)Travel Award   日本血液學(xué)會(huì)

2011.1   2010年度科研創(chuàng)新獎(jiǎng)   北京市道培醫(yī)院

2010.9   第72屆日本血液學(xué)年會(huì)Travel Award   日本血液學(xué)會(huì)

2010.3   2009年度最佳學(xué)術(shù)論文獎(jiǎng)   北京市道培醫(yī)院

2009.1   2008年度優(yōu)秀員工   北京市道培醫(yī)院

2008.1   2007年度突出貢獻(xiàn)員工（第一名）   北京市道培醫(yī)院

2008.1   2007年度開拓創(chuàng)新獎(jiǎng)   北京市道培醫(yī)院

編著及論文：

學(xué)術(shù)論文（近3年） @通訊/共同通訊作者；#共同第一作者

1.@王芳, 房建成, 許媛麗, 李婷婷,劉紅星. 三種統(tǒng)計(jì)指標(biāo)在 IGH 免疫組庫分析中的應(yīng)用. 中國(guó)免疫學(xué)雜志, 2018.34(11):1720-3. [DOI: 10.3969/j.issn.1000-484X.2018.11.025]

2.@王磊, 孫文利, 劉紅星.  高效液相色譜-串聯(lián)質(zhì)譜法測(cè)定移植患者血漿泊沙康唑水平. 檢驗(yàn)醫(yī)學(xué)與臨床, 2018.15(19):2902-5. [DOI: 10.3969/j.issn.1672-9455.2018.19.017]

3.@Xue Chen, Fang Wang, Yang Zhang, et al. Panoramic view of common fusion genes in a large cohort of Chinese de novo acute myeloid leukemia patients, Leukemia & Lymphoma. 2018, Online Published. [DOI: 10.1080/10428194.2018.1516876] [PMID: 30277115]

4.@Yang Zhang, Fang Wang, Xue Chen, et al. Mutation profiling of 16 candidate genes in de novo acute myeloid leukemia patients. Front. Med. 2018, Online Published. [DOI:10.1007/s11684-018-0616-1] [PMID: 29806051]

5.@Xue Chen, Fang Wang, Yang Zhang, et al. Retrospective analysis of 36 fusion genes in 2,479 Chinese patients of de novo acute lymphoblastic leukemia. Leukemia Research. 2018(72):99-104. [DOI:10.1016/j.leukres.2018.08.009] [PMID: 30125757]

6.@Yang Zhang, Fang Wang, Xue Chen, et al. CSF3R mutations are frequently associated with abnormalities of RUNX1, CBFB, CEBPA, and NPM1 genes in acute myeloid leukemia. Cancer. 2018, 124(16):3329-38. [DOI: 10.1002/cncr.31586] [PMID:29932212]

7.@Xue Chen, Fang Wang, Yang Zhang, et al. Genetic variant spectrum in 265 Chinese patients with hemophagocytic lymphohistiocytosis: molecular analyses of PRF1, UNC13D, STX11, STXBP2, SH2D1A, and XIAP. Clinical Genetics. 2018, 94(2):200-12. [DOI: 10.1111/cge.13363] [PMID: 29665027]

8.@陳雪, 王芳, 房建成, 等. 595例初診兒童急性髓系白血病患者36種融合基因篩查分析[J]. 臨床與病理雜志,2018,38(6):1202-7. [DOI:10.3978/j.issn.2095-6959.2018.06.011]

9.@王磊, 劉紅星. HPLC-MS/MS法測(cè)定患者血漿中伊曲康唑和羥基伊曲康唑濃度[J]. 臨床合理用藥雜志,2018,11(6):4-6.

10.@王磊, 劉紅星. 應(yīng)用HPLC-MS/MS法測(cè)定骨髓移植患者的血漿伏立康唑濃度[J]. 中國(guó)實(shí)用醫(yī)刊,2018,45(9):30-3. [DOI:10.3760/cma.j.issn.1674-4756.2018.09.010]

11.@張建平, 楊君芳, 王芳,  等. 1392例初診兒童急性淋巴細(xì)胞白血病患者36種融合基因篩查分析[J]. 臨床與病理雜志,2018,38(5):956-60. [DOI:10.3978/j.issn.2095-6959.2018.05.008]

12.@王磊，孫文利，李培余，等. Elecysis與HPLC-MS/MS檢測(cè)骨髓移植患者環(huán)孢素A血藥濃度的相關(guān)性及其應(yīng)用意義[J]. 中華臨床實(shí)驗(yàn)室管理電子雜志,2018,6(2):99-103. [DOI: 10.3877/cma.j.issn.2095-5820.2018.02.007]

13.@王磊，姜春菲，甄成亮，等. 白血病患者伏立康唑血藥濃度監(jiān)測(cè)的回顧性研究[J]. 中華臨床醫(yī)師雜志（電子版）,2018,12(3):156-9. [DOI:10.3877/cma.j.issn.1674-0785.2018.03.007]

14.@王磊，劉紅星. 高效液相色譜-串聯(lián)質(zhì)譜法測(cè)定患者血漿萬古霉素濃度[J]. 臨床檢驗(yàn)雜志（電子版）, 2018,7(1):17-19.

15.@王磊，王紅春，李培余，等. 兩種檢測(cè)骨髓移植患者環(huán)孢素A血藥濃度方法的比較[J]. 中華臨床實(shí)驗(yàn)室管理電子雜志,2017,5(4):240-4. [DOI: 10.3877/cma.j.issn.2095-5820.2017.04.010]

16.@劉銘，張陽，王芳，等. 骨髓增生異常綜合征患者常見突變基因的突變組分析[J]. 臨床與病理雜志,2017,37(11):2332-8. [DOI:10.3978/j.issn.2095-6959.2017.11.008]

17.@Xue Chen, Yang Zhang, Fang Wang, et al. Germline cytotoxic lymphocytes defective mutations in Chinese patients with lymphoma [J]. Oncology Letters,2017,14(5):5249-56. [DOI: 10.3892/ol.2017.6898]

18.@王磊，劉紅星，孫文利. HPLC-MS/MS法在骨髓移植患者全血CSA及AML1濃度測(cè)定中的應(yīng)用[J]. 重慶醫(yī)學(xué),2017,46(23):3234-7. [DOI:10.3969/j.issn.1671-8348.2017.23.021]

19.@王磊，劉紅星，孫文利. HPLC-MS/MS在骨髓移植患者他克莫司血藥濃度檢測(cè)中的應(yīng)用[J]. 現(xiàn)代檢驗(yàn)醫(yī)學(xué)雜志,2017,32(2):126-30. [DOI:10.3969/j.issn.1671-7414.2017.02.035]

20.@王磊，孫文利，李培余，等. 環(huán)孢素A血藥濃度檢測(cè)方法比較分析[J]. 中華臨床醫(yī)師雜志：電子版.2017;11(3) :417-21. [DOI:10.3877/cma.j.issn.1674-0785.2017.03.013]

21.@姜春菲，劉梅，魏娜，等. 血液病基因檢測(cè)臨床應(yīng)用的認(rèn)知程度調(diào)研報(bào)告[J]. 國(guó)際臨床報(bào)告,2016,3(2):1-6. [DOI: 10.14725/gjcr.v3n2a1659]

22.@張陽，陳雪，王彤，等. 伴先天易感因素和復(fù)雜基因突變的難治復(fù)發(fā)兒童急性髓系白血病一例并文獻(xiàn)復(fù)習(xí)[J]. 白血病?淋巴瘤,2016,25(12):743-5. [DOI:10.3760/cma.j.issn.1009-9921.2016.12.010]

23.@王磊，周楓葉，姜春菲，等. HPLC-MS/MS法測(cè)定白血病患者血漿伊馬替尼和達(dá)沙替尼濃度[J]. 現(xiàn)代檢驗(yàn)醫(yī)學(xué)雜志,2016,31(1):128-31. [DOI:10.3969/j.issn.1671-7414.2016.01.037]

約稿/專論/述評(píng)/綜述（近3年）

24.@Hongxing Liu, Yu Zhang. From Targeted Testing to Targeted Analysis: The Era of Comprehensive Clinical Genomics Analysis Is Coming. Genetics and Molecular Biology Research. 2018; 1(1): 3.

25.@Zhang Y, Wang F, Zhang Y, et al. Ongoing Development of Tumor Mutaome Analysis and Targeted Cocktail Therapy. J Clin Pathol Forecast. 2018; 1(1): 1001.

26.@Chen JQ, Wang F, Chen X, et al. The Rising Applications of Pharmacogenomics based Personalized Medication Fingerprints in Malignancies. J Clin Pathol Forecast. 2018; 1(1): 1002.

27.@劉紅星，王芳，聶代靜. 血液系統(tǒng)疾病基因組學(xué)分析及臨床應(yīng)用進(jìn)展[J]. 白血病?淋巴瘤,2018,27(2):69-71. [DOI:10.3760/cma.j.issn.109-9921.2018.02.002]

28.@周曉蘇,鄭旺良,劉紅星. 基于腫瘤新生抗原的免疫治療在血液腫瘤中的應(yīng)用前景[J]. 白血病?淋巴瘤,2018,27(2):80-2. [DOI:10.3760/cma.j.issn.109-9921.2018.02.005]

29.@張陽，劉銘，劉紅星. 骨髓增生異常綜合征中常見的基因突變及其臨床意義[J]. 臨床與病理雜志,2017,37(11): 2237-42. [DOI: 10.3978/j.issn.2095-6959.2017.10.035]

30.@張陽，劉紅星. 液體活檢在淋巴瘤中的研究和應(yīng)用進(jìn)展[J]. 中國(guó)實(shí)驗(yàn)血液學(xué)雜志,2017,25(4):125

9-63. [DOI:10.7534/j.issn.1009-2137.2017.04.054]

31.@陳雪，劉紅星. 精準(zhǔn)理解和探究遺傳致病因素:從孟德爾遺傳病到遺傳易感[J]. 中華臨床醫(yī)師雜志：電子版.2017;11(3) :516-8. [DOI:10.3877/cma.j.issn.1674-0785.2017.03.036]

32.@劉紅星，陳雪，王芳. 免疫組庫分析在血液腫瘤中的研究和應(yīng)用進(jìn)展[J]. 白血病?淋巴瘤,2017,

26(2):68-70. [DOI:10.3760/cma.j.issn.109-9921.2017.02.002]

33.@劉紅星，張陽，陳雪. 端粒和端粒酶在血液系統(tǒng)疾病中的研究進(jìn)展[J]. 白血病?淋巴瘤,2017, 25 (1):12-14. [DOI:10.3760/cma.j.issn.109-9921.2017.01.005]

34.@Yang Zhang, Yu Zhang, Hongxing Liu. Advances in Research and Application of Liquid Biopsy in Lymphoma. International Journal of Medical Reviews. 2016;3(4):501-503. [DOI: 10.15171/ijmr.2016.10]

35.@張陽，陳雪，劉紅星. 慢性粒細(xì)胞白血病靶向治療和靶向雞尾酒療法研究進(jìn)展[J]. 白血病?淋巴瘤,2016,25(10):632-6. [DOI:10.3760/cma.j.issn.109-9921.2016.10.018]

36.@周楓葉，張陽，劉紅星. 血液腫瘤相關(guān)藥物基因組學(xué)研究和應(yīng)用進(jìn)展[J]. 中華臨床醫(yī)師雜志：電子版.2016;10(14) :2145-9. [DOI:10.3877/cma.j.issn.1674-0785.2016.14.023]

37.@張玉便，陳雪，劉紅星. 人類皰疹病毒8型相關(guān)疾病及致病機(jī)制研究進(jìn)展[J]. 中華臨床醫(yī)師雜志：電子版.2016,10(14) :2180-3. [DOI:10.3877/cma.j.issn.1674-0785.2016.14.031]

38.@劉紅星，周楓葉，張陽. 血液腫瘤個(gè)體化用藥及相關(guān)遺傳藥物基因組學(xué)研究進(jìn)展[J]. 白血病?淋巴瘤,2016,25(7):385-8, 393. [DOI:10.3760/cma.j.issn.1009-9921.2016.07.001]

39.@陳雪，張陽，劉紅星. 陣發(fā)性睡眠性血紅蛋白尿癥發(fā)病機(jī)制、診斷及治療進(jìn)展[J]. 白血病?淋巴瘤,2016,25(4):252-6. [DOI:10.3760/cma.j.issn.1009-9921.2016.04.017]

40.@陳雪，竇丹丹，張陽，等. 兒童急性淋巴細(xì)胞白血病基因拷貝數(shù)變異研究及應(yīng)用進(jìn)展：第57屆美國(guó)血液學(xué)會(huì)年會(huì)報(bào)道[J]. 白血病?淋巴瘤,2016,25(3):139-43. [DOI:10.3760/cma.j.issn.1009-9921.2016.03.003]

參與編寫的國(guó)內(nèi)專家共識(shí)

41.中國(guó)抗癌協(xié)會(huì)血液腫瘤專業(yè)委員會(huì)、中華醫(yī)學(xué)會(huì)血液學(xué)分會(huì)、中華醫(yī)學(xué)會(huì)病理學(xué)分會(huì). 二代測(cè)序技術(shù)在血液腫瘤中的應(yīng)用中國(guó)專家共識(shí)（2018年版）[J]. 中華血液學(xué)雜志,2018,39(11):881-6. [DOI:10.3760/cma.j.issn.0253-2727.2018.11.001]

42.中國(guó)醫(yī)師協(xié)會(huì)檢驗(yàn)醫(yī)師分會(huì)造血與淋巴組織腫瘤檢驗(yàn)醫(yī)學(xué)專家委員會(huì). 造血與淋巴組織腫瘤檢驗(yàn)診斷報(bào)告模式專家共識(shí)[J]. 中華醫(yī)學(xué)雜志,2016,96(12):918-29. [DOI:10.3760/cma.j.issn.0253-2727.2013.07.022]

43.中華醫(yī)學(xué)會(huì)血液學(xué)分會(huì)實(shí)驗(yàn)診斷血液學(xué)學(xué)組. 血液病分子生物學(xué)診斷技術(shù)中國(guó)專家共識(shí)（2013年版）[J]. 中華血液學(xué)雜志,2013,34(7):643-6.

參編書籍

44.《臨床血液學(xué)檢驗(yàn)》，人民衛(wèi)生出版社，2017

45.《轉(zhuǎn)錄組學(xué)在精準(zhǔn)醫(yī)學(xué)中的應(yīng)用》，上海交通大學(xué)出版社，2017

46.《檢驗(yàn)診斷報(bào)告體系與應(yīng)用規(guī)范》，人民衛(wèi)生出版社，2017

國(guó)際會(huì)議報(bào)告（報(bào)告人或通訊作者）（近3年）

1.    Poster Presentation. Personalized Cyclosporine A disposition in One Patient with Allogeneic Hematopoietic Stem Cell Transplantation. The 2019 World Stem Cell Summit. Miami, America. Jan-23-2019.

2.    Poster Presentation. Exploration of Nutritional Indicators in Different Transplantation Periods of Leukemia patients. The 2019 World Stem Cell Summit. Miami, America. Jan-23-2019.

3.    Poster Presentation. Activated Infection Spectrums Analysis of Human Herpes Viruses in Patients with Various Immunodeficiencies. The 2019 World Stem Cell Summit. Miami, America. Jan-23-2019.

4.    Poster Presentation. Development and Application of an Automatic Analysis and Surveillance Platform for Chrimerism in Donors and Recipients post allo-HSCT. The 2019 World Stem Cell Summit. Miami, America. Jan-23-2019.

5.    Poster Presentation. Copy Number Monitoring from Tumor-Only Targeted Gene Sequencing in Hematological Malignancies. Abstract #4086. The 60th Annual Meeting of American Society of Hematology. San Diego, America. Dec-1-2018.

6.    Poster Presentation. Analysis of Molecular Minimal Residual Disease in Patients with Acute Leukemia during Complete Remission. Abstract #2781. The 60th Annual Meeting of American Society of Hematology. San Diego, America. Dec-2-2018.

7.    特邀發(fā)言. CSF3R Mutations Are Highly Concomitant with Transcription Factor Genes Abnormalities in Acute Myeloid Leukemia. The International Conference on Disease Biomarkers and Precision Medicine-2018. Houston, Oct-23,2018.

8.    Poster Presentation. Benefits in the Surveillance of the Copy Number of RUNX1 in childhood B-ALL Patients from Targeted Gene Sequencing. The 2018 American Society of Human Genetics Meeting. San Diego, Oct-17-2018.

9.    Poster Presentation. Molecular Characteristic of FLT3 Mutations in Acute Leukemia. The 80th Annual Meeting of the Japanese Society of Hematology. Osaka, Japan. Oct-12-2017.

10. Poster Presentation. Correlation analysis of Gene Mutation and clinical characteristics in Myelodysplastic Syndrome. The 80th Annual Meeting of the Japanese Society of Hematology. Osaka, Japan. Oct-12-2017.

11. 特邀發(fā)言. CSF3R Mutations Are Frequently Associated with Abnormalities of RUNX1, CBFB, CEBPA, and NPM1 Genes in Acute Myeloid Leukemia. The 23rd World Congress on Advances in Oncology. Athens, Greece. Sep-21,2018.

12. Poster Presentation. Analysis of donor chimerism in fingernails of recipients after allogeneic hematopoietic stem cell transplantation. The 44th Annual Meeting of Korean Cancer Association. Seoul, Korea. Jun-22, 2018

13. Poster Presentation. Genetic variant spectrum in 265 Chinese patients with Hemophagocytic Lymphohistiocytosis: molecular analysis of PRF1, UNC13D, STX11, STXBP2, SH2D1A and XIAP. The 44th Annual Meeting of Korean Cancer Association. Seoul, Korea. Jun-21, 2018

14. Poster Presentation. Analysis of donor chimerism in fingernails of recipients after allogeneic hematopoietic stem cell transplantation. The 2018 World Stem Cell Summit. Miami, America. Jan-23-2018.

15. Poster Presentation. CSF3R Mutation in Acute Leukemia and MDS Patients. The 59th Annual Meeting of American Society of Hematology. Atlanta, America. Dec-10-2017.

16. Oral Presentation. Analyze 36 fusion genes in 6170 de novo acute leukemia and myeloid neoplasms cases during 14 years. The 79th Annual Meeting of the Japanese Society of Hematology. Tokyo, Japan. Oct-20-2017.

17. Poster Presentation. The study of the applicability of three statistical methods in IGH immune repertoire analysis. The 2017 American Society of Human Genetics Meeting. Orlando, Oct. 20, 2017.

18. Poster Presentation. Analysis of germ line predisposition in Chinese children with bone marrow failure. The 2017 American Society of Human Genetics Meeting. Orlando, Oct. 19, 2017.